The Reds have instead flown to London and, once there, will fly straight back down to South Africa.
All up, it means the team's arrival in Cape Town will be delayed about 15 hours.
Coach Brad Thorn took the opportunity to reinforce some pre-season messages, gathering his players in Sao Paolo and encouraging them to embrace the adversity.
The Reds will be hunting a fourth straight win when they face the Stormers at Newlands on Sunday morning (NZT).
"We're just going to throw the kitchen sink at it and give it our all," said Queensland's South African-born prop Ruan Smith.
"There's a lot of guys in the group who haven't played there and your first time playing in Cape Town, it's always special.
"It's a big crowd always, an enjoyable stadium to play in.
"We're just going to go out and enjoy it. We've got nothing to lose."