The NRL had teams move into bubbles in Queensland, but with the new outbreak, it has thrown the future of the competition up in the air.
The state had already played host to a number of games in Round 20 of the NRL, but the rest of the round has been shut down.
The NRL is reportedly conducting emergency talks with the Queensland government to seek exemption for the competition to continue.
The full list of cancelled NRL games include the Newcastle Knights v Canberra Raiders, Melbourne Storm v Penrith Panthers, Canterbury Bulldogs v Gold Coast Titans and the Cronulla Sharks v Manly Sea Eagles.