It is understood Chambers has the inside running after a disappointing return from injury for O'Neill last week.
Meanwhile, interchange players Klemmer and Shannon Boyd are in line to partner Woods at prop. Sam Thaiday, who missed last year's final with a fractured eye socket, is expected to return to the side on the interchange bench.
Meanwhile, England coach Wayne Bennett is on the verge of selecting former Queensland Origin back-rower Chris McQueen. McQueen, who played the last of his six Origin matches in 2014, is set to play for England against Samoa on May 6.
Likely Kangaroos side:
Darius Boyd, Valentine Holmes, Josh Dugan, Will Chambers/Justin O'Neill, Blake Ferguson, Johnathan Thurston/James Maloney, Cooper Cronk, Aaron Woods, Cameron Smith, David Klemmer/Shannon Boyd, Matt Gillett, Boyd Cordner, Trent Merrin. Interchange: Klemmer/Boyd, Sam Thaiday, Michael Morgan, Tyson Frizell.