A tireless Mystics side continued their strong performance to dominate the final 15 minutes, forcing the usually disciplined Stars into errors.
A late Stars surge aided by Elle Temu's impressive defensive plays failed to come in time to give the hosts any chance of holding off the Mystics' conclusive eight-goal win.
Mystics captain Sulu Fitzpatrick wasn't taking the win lightly, instead turning her attention to this week's clash which will see the two sides meet again in Auckland
"The scoreline doesn't reflect how hard the game was," Fitzpatrick said. "I know they're going to come at us again next week."
Stars captain Maia Wilson was optimistic despite the loss that toppled her side from the top of the table, also looking towards next week's game as an opportunity to improve on their latest performance.
"I feel like there is so much more for us to grow and we can come back and be better," Wilson said.
The two sides meet again on Sunday at Trusts Arena, where the Stars will have a chance to reclaim top spot.
The Southern Steel host the Waikato Bay-of Plenty Magic tomorrow night, while Tuesday's match between the Central Pulse and Mainland Tactix has been postponed due to the extension of Wellington's Level 2 Covid-19 status.