Wilson says she's looking forward to spending more time with her family and contributing to netball in a different capacity.
"I have thoroughly enjoyed my time at the Mystics and I love working with the players, and watching them grow and develop as athletes but also, more importantly, as people.
"I will miss them and my wonderful coaching and management team. However, the opportunity at High Performance Sport is exciting and one I know I feel just as passionately about.
"The chance to help develop and grow opportunities for women in high performance sport is obviously something very close to my heart."
The recruitment process for a new head coach will begin shortly.