Inter conceded top spot in Serie A to Napoli, who are favourites to claim the domestic league title, after getting past Bayern while AC Milan dumped them out of the Italian Cup a fortnight ago.
But Inter ended Barca’s hopes for the quadruple and now head into the final weeks of the season buoyant with a second Champions League final in three seasons to look forward to.
Frattesi’s winning goal, his seventh of the season and probably the most important of his career, was all the more incredible for the fact that Inter should by rights have already been eliminated.
The hosts were heading out with two minutes remaining of regular time when Raphinha completed a comeback from two goals down at half-time and gave Barca a 3-2 lead on the night.
But Francesco Acerbi stunned everyone in the stadium, not least the already-celebrating Barca supporters, when he forced home Denzel Dumfries’ cross in the second minute of added time.
That goal came as a bolt from the blue as Barca had been by far the better team in the second half of normal time after going in at the break behind to a brilliant Lautaro Martinez goal and Hakan Calhanoglu’s penalty in first half stoppage-time.
Eric Garcia and Dani Olmo pulled Barca level with goals in the 54th and 60th minutes, both from sumptuous Gerard Martin deliveries, and Yann Sommer had to be at his best to keep Inter within touching distance.
Sommer made possibly the save of the season between Barca’s first two goals, somehow stopping Eric Garcia from finishing off a lightning Barca counter-attack.
And the Swiss ended up being crucial again in the 113th minute when he pulled off another miraculous save from Lamine Yamal, who hit the post just before Acerbi’s equaliser.
Inter then held off Barca as the home fans held their breath before unleashing a mighty roar at the final whistle of the match of the season.
