Their legs could be protected for the run by drafting off a fellow New Zealander on the bike.
A strong rider like Samuels — the 2012 national road racing champion — could help haul in breakaway groups.
However, just six Commonwealth athletes were ahead of the 14th-ranked Samuels last season, meaning she might consider contesting the race on her own. The 15th-ranked McIlroy remains an unknown quantity after heel surgery last year.
A co-ordinated men's race plan has seen Davison selected to support Sissons.
In Auckland this month, Sissons was the fourth-slowest race finisher in the swim but Davison helped him recover on the bike.
Sissons eventually came sixth. Davison was rewarded for his selflessness.
A similar concept succeeded at the Beijing Olympics where Shane Reed's efforts helped Bevan Docherty to a bronze medal.
The mixed relay is viewed as New Zealand's best medal chance at Glasgow. The quartet of Hewitt, McIlroy, Sissons and Dodds earned silver at last year's world championships in Hamburg, behind the hosts and ahead of the US.
Meanwhile, Hewitt's partner, Laurent Vidal remained in an induced coma last night after suffering a heart attack training on Friday. Hewitt was due to arrive at his bedside this morning.