Confessing that he had taken cocaine and marijuana before the bout, he says: "I had to use my whizzer, which was a fake penis where you put in someone's clean urine to pass your drug test."
He blamed a US$200,000 ($241,000) fine for testing positive for marijuana after a 2000 fight against Andrew Golota in Detroit on the fact that he was tested before having a chance to get the "whizzer" from a member of his team, whom he claims typically carried the device from fight to fight.
Tyson explains that he had taken cocaine before a notorious televised press conference with Lennox Lewis in New York in January 2002, which descended into a brawl.
"I lost my mind," Tyson recalls. "I looked over at him and wanted to hit the mother******."
As the pair of heavyweights tussled, Tyson bit Lewis's leg.
Tyson, the youngest boxer to win the WBC, WBA and IBF heavyweight titles, says he regrets that his drug use led to "Herculean" mood swings.
After years of rehabilitation treatment - between staging a one-man show, appearing in the film The Hangover and socialising with A-list celebrities such as Victoria Beckham - Tyson said in August this year that he was close to death due to his chronic alcoholism.