It is set in a pub. One character decides he's had enough, and tells his friend "yeah, nah" when offered a beer.
A montage unfolds, featuring karaoke and light-hearted fun.
"We watch the night unfold through the eyes of the first man as he imagines the night ahead," the Health Promotion Agency said. "The friends have a great night despite his mate's decision to ease up."
Agency spokesman Tane Cassidy said the phrase gave people the language to allow them to refuse a drink in a socially acceptable way.
"It is a uniquely Kiwi way of saying 'no' and affirms an individual's decision not to drink," he said.
The 60-second commercial was created by DraftFCB, the agency also behind the "ease up on the drink" ads.
Cassidy said the campaign would include bus shelter ads and street posters and cost about $1.3 million.
Its effect would be reviewed at the end of next month.