Police would like to hear from anyone who was in the area at the time and witnessed the crash or anyone who may have dashcam footage,” said a police spokesperson.
Police told the Herald the crash involved a B-train truck and trailer and a car.
Hato Hone St John was responding with a helicopter to the scene. One patient was treated and one was taken to Dunedin Hospital, St John said.
A Fire and Emergency spokesperson said one of the vehicles was on fire.
“Crews from Waimate, St Andrew’s and Timaru are working to extinguish the blaze, while also assisting St John and police.”
The highway was closed between Hook Swamp Rd and Hook Station Rd for much of the day.