The incident happened on Thomas Rd around 11.45am.
Police said cordons were now in place where the incident occurred and these were expected to be in place for some time.
At least two streets have been closed by the incident.
Auckland Transport said a section of Thomas Rd in Māngere was closed. Jordan Rd was also closed to traffic.
Motorists were told to avoid the area or allow extra time for diversions.
The Serious Crash Unit was now examining the scene.
Police were currently making enquiries inot the vehicle involved in the incident.
"These enquiries are still in the early stages and a further update will be provided once available," said a police spokesperson.