It is not yet known how many vehicles were involved in the crash.
Motorists in the area are being warned to use alternative routes as the road is expected to be closed for "some time," police said in a statement.
The Serious Crash Unit is due to carry out a scene examination this morning.
Police are also responding to a single-vehicle crash on Henderson Valley Rd.
The incident was reported about 5.20am.
Police said the car involved crashed into a power pole and lines were down as a result.
"There are no reported injuries. However, the road will be closed while the lines are fixed."
Motorists are told to avoid the area, if possible.