Health spokesman Shane Reti will take over Bishop's Covid-19 portfolio responsibilities to free him up for it. The Covid-19 portfolio had been less of an onerous role as the Government scaled back its response, and this week dropped most remaining restrictions and the traffic light system.
Bishop takes on the role that was performed by National's campaign maestro, former National MP Steven Joyce, for five elections, including when Sir John Key was leader.
"Chris Bishop is a formidable talent and has the right mix of skills and relentless energy to chair our campaign for the 2023 General Election," Luxon said.
He said the campaign would focus on National's desire to rebuild the economy and deliver effective public services.
Bishop will be up against Labour's campaign chair, senior minister Megan Woods, who was also campaign chair for the 2017 and 2020 elections and will again work alongside campaign manager Hayden Munro.
The National Party is also expected to use its former campaign manager Jo de Joux again this election - de Joux was the party's campaign manager in the successful 2008, 2011 and 2014 elections.
Bishop, 39, has been an MP since 2014. He was originally a List MP, but won the Hutt South electorate in 2017 - only to lose it to Labour again in 2020.
Bishop is also National's Shadow Leader of the House and spokesman for Housing and Infrastructure.