Three rescue helicopters were sent to the scene of the two-car crash, which left the road blocked in both directions.
The injuries of the five hurt ranged from critical to minor, a police spokeswoman said.
Two people were in one of the vehicles and five in the other.
Emergency services were alerted to the crash between Waikite Valley Rd and
Waikaremoana Rd about 7.15pm on Tuesday.
The spokeswoman said fire and ambulance staff were also at the scene. Rescue helicopters were being sent from Tauranga and Taupō.
The Serious Crash Unit were also sent to the scene.
Meanwhile, one person also suffered serious injuries in a crash at Haumoana in Hawke's Bay yesterday.
The two-vehicle collision occurred near the intersection of Haumoana Rd and
Parkhill Rd about 7.45pm on Tuesday.
One person has sustained serious injuries, another moderate injuries.