SCFAs are associated with a number of health benefits, including the stimulation of cells to produce antimicrobial peptides called defensins, which play an important role in immune protection.
The research showed higher concentrations of defensins in the gut tissues of the avocado-fed rats.
Although this wasn't solid proof of beneficial activity in the body itself, higher levels were probably better for gut health, study co-leader Dr Gunaranjan Paturi said.
Another change to the gut lining had more straightforward benefits.
SCFAs are also the fuel for goblet cells, which produce mucus in a healthy gut that protect gut tissue.
The team found significantly more goblet cells in the gut wall in rats on the 15 per cent avocado diet, something that implied the fruit also positively influenced gut mucus secretion, Paturi said.
As the trial was working with a known safe and beneficial food, Paturi said the next step could be a move straight into testing with humans.
"This is exciting research," New Zealand Avocado chief executive Jen Scoular said.
"It potentially opens the door to a whole new area of benefit we hadn't seen before.
"It would be great to see this research followed up to find out if it translates into real benefits for human gut health."
The research was funded as part of MBIE's Food for Health programme and published in the journal Plant Foods for Human Nutrition.