"You've made my days brighter and filled this experience with so much joy," she continued.
"'Keep finding those Tig moments of discovery, keep laughing and taking risks, and keep being "the change you wish to see in the world."
"Above all, don't ever forget your worth - as I've told you time and time again: you, my sweet friend, you are enough. Thank you for everything."
The actress signed the note 'Xx Meghan Markle', and a page featuring her letter along with a collage of images is now the only thing left on the site.
Meghan shared a similar sentiment on her Instagram page, but instead of posting photos from her blog, she shared images of her supporters.
Although her fans are undoubtedly disappointed to hear the news, many commenters wished her well as she embarks on the next chapter of her life.
And people see The Tig's closure as a sign that Prince Harry is about to propose.
"I wish you happiness in life & marriage. God bless your growing family," Jennifer Oakes wrote. 'Nevermind the people who would see you remain single forever, with marriage comes sacrifice (both sides).'
Meanwhile, other deduced the actress is simply focusing on her humanitarian work and her role on Suits.
When she first launched The Tig three years ago, Meghan explained that she came up with the blog's unusual name after trying a wine called Tignanello, which is nicknamed 'Tig'.
"It was an ah-ha moment at its finest. For me, it became a "Tig" moment - a moment of getting it,' she wrote on her blog, explaining that the wine helped her truly understand what experts mean when they they are references 'the body, legs, structure of wine".
The lifestyle blog covered everything from food and travel to beauty, and many fans noted they would miss her inspiring posts that were often very personal.
For one of her final posts, Meghan took to her blog early Wednesday morning to share a series of lifestyle quotes tagged under 'Thoughts to live by'.
The actress appeared to have given an insight into her relationship philosophy, and at the top of the list was "overplanning kills magic" - perhaps a not-too-subtle nod to her relationship with the flame-haired prince.
Her favorite life-inspiring quotes were billed 'itty-bitty tidbits of wisdom we offer to lift daily spirits and inspire each of us to reach our full potential".
In February, when she celebrated her first Valentine's Day with Prince Harry, the divorcee issued advice to lonely hearts in a re-submitted post entitled, "Be Your Own Valentine."
The piece, which was written in 2015 when Meghan was single, appeared to be re-posted as a morale booster for those who were not quite as lucky in love as she.
In the two-year-old post, Meghan revealed that she would be spending Valentine's Day in the West Village drinking cocktails - a far cry from the royal celebrations she most-likely enjoyed this year.
In a hope to offer her fellow single reader some comfort she advised her fans to treat themselves on the big day.
"I think you need to cook that beautiful dinner even when it's just you, wear your favorite outfit, buy yourself some flowers, and celebrate the self love that often gets muddled when we focus on what we don't have," she wrote.
As her relationship with Prince Harry continued to bloom, numerous media outlets looked back at some of her older blog posts, including a resurfaced story about the dream bachelorette vacation she planned for a friend.
Before it was revealed that she was dating the prince, Meghan wrote about planning an intimate getaway as her friend Lindsey's maid of honor.
"The thought of running around a city trying to get into clubs and wearing headbands of the phallic persuasion didn't seem very "on brand" for us, I opted instead to woo the bride to be with a more low-key stagette," she wrote on her lifestyle website in July.
Instead of tearing up the town, Meghan organized a weekend jaunt to Greece for the bride-to-be and their friend in June - just a month or so after she and Prince Harry had reportedly started dating.
The California-native explained that her friend Lindsey was spending have of her time in London, so it was easy for them to escape to the island of Hydra, which is a two-hour ferry from Athens.
Meghan lovingly described the island as a "little rock trapped in time with the only mode of transportation being bikes or donkeys".
The actress admitted that part of the appeal of Hydra was the serenity because there is not much to do aside from walking around the town, hiking, eating, swimming, and napping.
"There is something wholly cathartic about being able to turn it all off - to sunbathe with no one watching, swim in the briny Mediterranean Sea, eat copious amounts of Greek salads and fried red mullets, and toast to the day," she explained.
Meghan, who is based in Toronto, has been staying with her boyfriend at his Kensington Palace base where the pair have enjoyed a string of dates including a reported night at the Natural History Museum.
Prior to that, the pair enjoyed a romantic weekend in Jamaica together for the wedding of Harry's best friend, Tom 'Skippy' Inskip.
Meghan will start filming Suits next season this month but there are strong rumors she will quit after that in order to concentrate on her relationship with the Queen's grandson and her charity work.
