They went twice, at least one week apart, and either performed a mock rescue from a two-storey building for 20 minutes or did light duties, in the case of the control group, for 20 minutes.
The firefighters wore heart monitors that continuously assessed their heart rate and its electrical activity.
Blood samples were also taken before and after, including measurement of a protein called troponin that is released from the heart muscle when it is damaged.
Those taking part in the rescue had core body temperatures that rose by 1C and stayed that way for three or four hours.
There was also some weight loss among this group, while their blood vessels also failed to relax in response to medication.
Their blood became "stickier" and was more than 66 per cent more likely to form potentially harmful clots than the blood of people in the control group.
Dr Mike Knapton, associate medical director at the BHF, said: "Firefighters routinely risk their lives to save members of the public. The least we can do is make sure we are protecting their hearts during the course of their duties."
This story was originally publish by the Daily Telegraph.