"Young girls who, as pre-schoolers, had heightened cortisol levels, go on to show lower brain connectivity in important neural pathways for emotion regulation - and that predicts symptoms of anxiety during adolescence."
In contrast, young men were unaffected in later years by family stress in their early life, according to the research.
For the study, published in the journal Nature Neuroscience, Dr Burghy looked at 57 children - 28 female and 29 male - who had been part of long-running research by the university.
They found that girls with raised cortisol by the time they were four-years-old also had weaker brain connections. Scientists then discovered they had lived in homes where their mothers had reported higher general levels of stress, which could include symptoms of depression.
Dr Richard Davidson, a professor of psychology and psychiatry who works alongside Dr Burghy, said: "Our findings raise questions on how boys and girls differ in the life impact of early stress.
"We do know that women report higher levels of mood and anxiety disorders, and these sex-based differences are very pronounced, especially in adolescence."
- DAILY MAIL