The rapper, who was born Earl Simmons, suffered a heart attack on April 2 and spent the past week on life support at White Plains Hospital in New York.
"We are deeply saddened to announce today that our loved one, DMX, birth name ofEarl Simmons, passed away at 50 years old at White Plains Hospital with his family by his side after being placed on life support for the past few days," his family said in a statement.
"Earl was a warrior who fought till the very end. He loved his family with all of his heart and we cherish the times we spent with him. Earl's music inspired countless fans across the world and his iconic legacy will live on forever.
"We appreciate all of the love and support during this difficult time. Please respect our privacy as we grieve the loss of our brother, father, uncle and the man the world knew as DMX. We will share information about his memorial service once details are finalised."
— Chance The Rapper (@chancetherapper) April 9, 2021
Even though you had battles you TOUCHED so many through your MUSIC and when you would PRAY so many people FELT THAT! This is heavy for the HipHop family but your LEGACY LIVES ON & your SPIRIT. Continued Prayers for X family & friends for STRENGTH/HEALING🙏🏾 pic.twitter.com/ZI9NI6Nslg
The Grammy-nominated rapper shot to stardom in the early 1990s, with his debut album It's Dark and Hell Is Hot in 1998, which received critical acclaim and commercial success, selling 251,000 copies within its first week of release.
The rapper was most well known for his iconic tunes X Gon Give It To Ya and Ruff Ryder's Anthem.
He topped the charts numerous times, in the US and around the world, over the course of his career.