When she obliged, the 42-year-old actress left her co-star thinking she had "burst her appendix", prompting the hospital dash.
Sofia said: "I popped her ovary."
Elsewhere in the movie, Witherspoon, 39, had to speak in Spanish, much to the amusement of her Colombian co-star.
Speaking on The Ellen DeGeneres Show, Vergara said: "That was my favourite part of the movie, her speaking Spanish.
"Now I finally understand why I am so funny to the Americans."
And Witherspoon admitted Vergara couldn't fail to hide her scorn at her efforts.
She said: "She wasn't even nice about it. She was like, 'This is terrible. You sound terrible'."
- Bang! Showbiz