The film is about a giant prehistoric shark that attacks an international underwater observation program.
Variety reported Rose would play Rose "an engineering genius and a member of the marine research team" alongside Statham, "a former Naval captain and expert deep-sea diver"
Meg is due for a 2018 release and is directed by Jon Turtletaub. Chinese actress Fan Bingbing co-stars alongside Statham and Rose, and filming will also take place in China, Variety reports.
Rose began her career as an MTV presenter and dance DJ but has scored several major TV and film roles, including two seasons on Netflix hit Orange is the New Black.
She has three films due for release in 2017: XXX: Return of Xander Cage, John Wick: Chapter Two and Meg.