Musicians and other celebrities have taken to social media to send the rapper their well wishes and ask the world to "pray for DMX".
"Prayers for DMX and his family," Missy Elliott wrote on Twitter.
A chorus of other celebrities joined in on the well wishes, as the rapper remains in serious condition since being admitted to hospital on Friday (US time).
The 50-year-old rapper, who has fathered 15 children, remains in White Plains hospital in New York.
DMX has previously opened up about his addiction to crack cocaine, which began when he was 14 after he smoked a marijuana cigarette laced with the drug.
The rapper shot to stardom in the early 1990s, with his debut album It's Dark and Hell Is Hot in 1998, which received both critical acclaim and commercial success, selling 251,000 copies within its first week of release.
He has since topped the charts numerous times, in the US and around the world.
