It's Vogue's biggest and most influential edition, so important it has it's own documentary, The September Issue.
But in an unprecedented move, the style bible's editor-in-chief Anna Wintour has relinquished control over what is always the year's most talked about magazine cover - instead putting Beyonce in charge.
The surprise move is out of character for the infamously hands on editor, but is said to have been negotiated as a key part of Beyonce's contract, according to a Huffington Post report.
And the singer has used her power to give a career boost to 23-year-old black photographer Tyler Mitchell, recruiting him to take her picture.
He is the first photographer of color to shoot a Vogue cover. The magazine is 126 years old and first featured color photos on it's cover in 1932.
Along with controlling the magazine cover, Beyonce's contract also states that she is to select the photos of her inside the magazine. She is also writing her own captions in long form, according to the Huff Post.
Mother-of-three Beyonce, 36, has appeared on Vogue's September issue cover once before, shot by Mario Testino in 2015.
The Crazy In Love singer and her husband Jay-Z are currently on their On The Run II tour, having turned the European leg of the concert into a family vacation.
Between gigs they relaxed in a series of incredible locations with Blue Ivy, six, and 12-month-old Rumi and Sir, sharing pics on Beyonce's website.
In one picture, Beyonce held her twins in her arms while Rumi smiled broadly and Sir looked down, but both tots faces could be seen clearly.
On another, taken from behind, 48-year-old Jay - whose real name is Shawn Carter - held his swimsuit-clad youngest daughter's hand as they looked out to sea on board a yacht.
The picture gallery - which was captioned "Thank You Europe" - also included a number of shots featuring the couple's oldest daughter.