His biggest success was to come in 1992 with the debut of The Larry Sanders Show, a critical and commercial hit, running for eight seasons on HBO. The program was a behind-the-scenes look at life for a fictional TV talk show host, and went on to influence a generation of comedy series, including 30 Rock, Extras and Curb Your Enthusiasm.
Shandling appeared less frequently on screens in recent years, but had a supporting role as Senator Stern in Marvel movies Iron Man 2 and Captain America: The Winter Soldier.
Hollywood's biggest comedy names have rushed to pay tribute to the star, with Ricky Gervais tweeting that he was "surely one of the most influential comedians of a generation":
Shandling was never married and divulged little about his personal life, but had a wide circle of famous friends. He was one of only a handful of people invited to attend Hollywood icon Farrah Fawcett's 2009 funeral.
- news.com.au