"I'm single ... I'm not sleeping with anyone," Star said. "This is so stupid. Let me just say this one time ... I like very tall men."
He continued: "Me and Kanye have never hung out, and this whole thing is really funny. I get why people are really laughing about this. In an old song of mine from 2009 called B***h Please, I say a line about Kanye.
"But it was very like Eminem. I mentioned like 50 celebrities."
Rumours started swirling earlier in the week that Star had been sleeping with Kanye, which is what led to the rapper's "imminent divorce" from Kim.
While Star has denied the rumours, he himself was adding fuel to the fire earlier in the week when he was posting cryptic messages on social media.
"I'm ready for Sunday Service," he quipped to his more than seven million followers, referring to Kanye's Sunday Service venture. He also shared a video of himself claiming to be in Wyoming, where Kanye also lives.
"I am here in the beautiful state of Wyoming," he said in the video.
As it turns out, Star has decided to live half of the year in Wyoming, and the other half in his home in California. This has no link to Kanye, as he addresses in the YouTube clip, and is a mere of a coincidence.
A source close to Kim and Kanye have even since told E! News: "There is absolutely no truth to Jeffree and Kanye rumours."
Following this week's bombshell divorce reports, a different source revealed to NBC News that Kim and Kanye are dealing with "regular relationship issues" and "There is no one else involved."
They also claimed the pair have "barely spent any time together" for months.
"They've seen each other for the sake of the kids, but have been living separately. Kim knows the marriage is over. She's known for a while," the source said.
It comes after several insiders revealed Kim has hired divorce lawyer to the stars Laura Wasser.
"They are keeping it low-key but they are done," said a source.
"Kim has hired Laura Wasser and they are in settlement talks."
Kim is allegedly suing for full custody of the couple's four kids, North, 7, Saint, 5, Chicago, 2, and Psalm, 1.
It's likely to be one of the most expensive splits in history with assets totalling $2.7 billion.
Reports suggest that they'll be wrangling over a huge property portfolio worth $118 million, a fleet of luxury cars and the profits of two multimillion-dollar companies.
Kim is also planning to hold on to the family home, an LA mansion valued at $75 million which they renovated together over four years.
