One angry fan wrote to the actress and humanitarian: "I was planning to watch the latest season of Homeland on a long flight next week, thanks for ruining that."
Another added: "I never thought I'd ever be mad at Mia Farrow, but she spoiled homeland tonight!"
Farrow has since taken to her account again to apologise and explained that she was only responding to tweets she saw from other fans of the show.
Listen I'm in Kenya & only saw #Homeland tweets- not the show. Sorry. #unspoiling
The Golden Globe-winning show received a critical mauling over its uneven third season, which is yet to screen in New Zealand after TV3's deal with Fox fell through.