KEY POINTS:
In the first season of Prison Break, we met Michael Scofield (Wentworth Miller), an engineer whose brother, Lincoln, was wrongly accused of murdering the Vice-President's brother and sentenced to death.
Michael had himself locked up in order to orchestrate an escape, consulting the prison blueprints he had had tattooed all over his torso.
Fellow prisoners willing to help included ex-mob boss Abruzzi, C-Note, Sucre and T-Bag.
Despite bonding with prison governor Pope, Michael attracted the suspicions of menacing prison guard, Captain Bellick.
On the outside, Lincoln's lawyer and one-time girlfriend Veronica attempted to unravel the conspiracy that sent her man to jail.
The group's first escape attempt didn't work but at the end of the season, they made it over the wall, where they sprinted for a plane to take them to Mexico.
The prison break was not without its consequences. Michael was forced to betray Warden Pope and prison doctor Sara Tancredi (his possible love interest) had a drug relapse and overdosed.
Long-serving inmate Westmoreland died of injuries sustained in the escape - but not before revealing where he had hidden more than $5 million in cash.
The second season continues the manhunt, as the inmates struggle to evade the vengeful Bellick and the FBI.
It's a battle of wits between Michael and Mahone, the federal agent who has figured out the significance of Michael's tattoo.
The political conspiracy of Lincoln's sentence continues to unravel, as does the battle to get to Westmoreland's buried loot.