"What I said was, had I known how successful it was before going, I think I would have chickened out because it was such an iconic show and I probably wouldn't have felt up to the job.
"But fortunately I went, I took a risk, I didn't know how big of a risk I was taking, and I had the most incredible experience."
With several sitcoms from the '90s and early 2000s being rebooted in the last few years including Full House, Will And Grace and Roseanne, Friends fans are desperate to see Ross, Rachel, Monica, Chandler, Phoebe and Joey reunite on the small screen.
The actors themselves are adamant it won't happen, but if it did and they wanted Janine Lecroix to be involved, would Macpherson oblige?
"Yeah, definitely," she told news.com.au inside the Lexus marquee.
Macpherson's comments about Friends were echoed by Dermot Mulroney who still gets recognised for his appearance on the sitcom, even though he was only in three episodes.
"I had a great time working on that show … It was only a brief appearance, but what I learned is that Friends is such a powerful show," he told Fox News.
"Maybe in the last year or two, it was released on a streaming service, so it was watched all over again by a new age group.
"I was recognised for what I remember being kind of a minor role, quite frequently," he said.
