Later on in the programme, the 50 First Dates actress brought up Harris’ endearing name for herself, urging the Vice President to be “Momala” of the United States.
“I keep thinking in my head that we all need a mum. I’ve been thinking that we really all need a tremendous hug in the world right now,” Barrymore shared as she moved closer to Harris.
“But in our country, we need you to be Momala of the country.”
The talk show host then took hold of Harris’ hand as the politician seemingly grinned uncomfortably.
Watchers of the show flooded social media with comments regarding the awkward moment, which has been dubbed “super creepy” and “weird” online.
“This is so embarrassing @DrewBarrymore is almost in her lap,” one person shared on X - formerly Twitter - while another chimed in, “This has got to be one of the cringiest things I’ve ever seen.”
A third person added, “If Drew got any closer to Momala, she’d be sitting in her lap,” while another questioned, “Have we reached peak cringe yet?”
Even X owner and SpaceX founder Elon Musk shared his two cents on the interaction, commenting a face palm emoji on the now-viral video.