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The germs can then be seen spreading through Springfield with the local news anchor Kent Brockman reporting: "The dreaded Osaka flu has hit Springfield with over 300 cases now reported."
The same episode also features what fans believe is a link to Kobe Bryant's fatal helicopter crash, which killed the basketballer and his daughter.
As the town ends up in a state of panic because of the outbreak, a news reporter in a helicopter repeatedly says the phrase "going around and around" which theorists claim are a direct reference to what happened to Kobe Bryant's helicopter before it crashed.
People on Twitter were quick to share the similarities between the episode and the real-life virus, despite the fact that the coronavirus came from China and not Japan.
Some even photoshopped coronavirus onto The Simpsons local report.
A new strand of the coronavirus, which originated in Wuhan, China, has killed at least 304 people, with at least 14,380 infected by the virus.
There are no confirmed cases of the coronavirus in New Zealand as of yet.
Other episodes where The Simpsons predict the future include Donald Trump being president of the United States, 911, US beating Sweden in Olympic curling and Lady Gaga's half-time Super Bowl show.