The South African comic, 38, began his lengthy response in the comment section of the rapper's now-deleted post referring to the host with a racialslur, reports the New York Post.
"Damn, here we go again," Noah wrote before praising West's musical talent and sharing how his work has affected his life.
"I thought differently about how I spent my money because of you, I learned to protect my child-like creativity from grown thoughts because of you, s*** I still smile every time I put on a seatbelt because of you," the Comedy Central personality shared.
Noah went on to say that it "breaks my heart to see you like this".
"I don't care if you support Trump and I don't care if you roast Pete. I do however care when I see you on a path that's dangerously close to peril and pain."
Kanye West attacked Trevor Noah on social media for speaking out in support of Kim Kardashian. Photo / Getty Images
He implored the rapper to learn the difference between fighting for his family and fighting with them, adding that the latter often leads to disaster.
"I've woken up too many times and read headlines that about men who've killed their exes, their kids and then themselves. I never want to read that headline about you."