Cuoco, 35, began dating Cook in 2016, a year before they got engaged on her birthday in November 2017.
The couple then tied the knot on June 30, 2018, in a ceremony at a horse stable near San Diego, California, with close friends and family in attendance.
In June this year, the couple celebrated their three-year wedding anniversary with sweet tributes on social media.
The "Flight Attendant" star wrote: "NY, June 30th, 2016 is the year we met. 2 years to the day before we got married and now 3 years married! Why have you stayed married to me for so long?! I'm sincerely impressed @mrtankcook lol I love you oh so much you have no idea…happy anniversary!!!"
And Cook had added: "I agree @kaleycuoco I am just as amazed it's been three years, feel like just a flash. I love you so much and I can't wait for a million more years!!"
Cuoco's marriage to Cook was her second after previously being married to Ryan Sweeting from 2013 to 2016.