Anjelica believes the director wasn't in an "unusual situation" and he should be allowed to move on now.
She told New York magazine: "It's a story that could've happened ten years before in England or France or Italy or Spain or Portugal, and no one would've heard anything about it. And that's how these guys enjoy their time.
"It was a whole playboy movement in France when I was a young girl, 15, 16 years old, doing my first collections. You would go to Régine or Castel in Paris, and the older guys would all hit on you. Any club you cared to mention in Europe.
"It was de rigueur for most of those guys like Roman who had grown up with the European sensibility...
"My opinion is: He's paid his price, and at the time that it happened, it was kind of unprecedented. This was not an unusual situation."
Anjelica went on to defend her former 'Transparent' co-star Jeffrey Tambor, who was accused of inappropriate behaviour by both an actress on the show and a former assistant, insisting she didn't feel he had done anything wrong.
She said: "I've met them both. At least insofar as I was concerned, nobody did or said anything inappropriate.
"I do think in this work we have to feel freedom. We have to feel as though we can say and do things that are not necessarily judged, particularly by the other people in the cast or crew."
Anjelica clarified she felt the rules of behaviour on a TV or a film set should be regarded differently to those in a corporate environment and asked if she felt that was a fair defence if Jeffrey felt some of what he had said had been misinterpreted, she added: "Yes, that is fair. He certainly never said or did anything inappropriate with me."
-Bang! Showbiz