The recent holiday season dealt another blow to the embattled company, which struggled to find its footing even as the retail industry racked up its largest gains in years.
In January, Toys R Us announced it would close 182 U.S. stores, or about one-fifth of its remaining locations.
Despite turnaround efforts at Toys R Us, which included adding more hands-on "play labs," retail experts say the 60-year-old company has been unable to get customers back into its stores.
It doesn't offer the low prices or convenience of some of its larger competitors, nor the fun-filled experience that many smaller outfits do, some analysts have said.
Toys R Us, based in Wayne, New Jersey, has been struggling for years to pay down billions of dollars in debt as competitors like Amazon, Walmart and Target win over an increasingly larger piece of the toy market. Its bankruptcy filing cited US$7.9b in debt against US$6.6b in assets.
The company said it has more than 100,000 creditors, the largest of which are Bank of New York (owed US$208 million), Mattel (US$136m) and Hasbro (US$59m).
"The liquidation of Toys R Us is the unfortunate but inevitable conclusion of a retailer that lost its way," Neil Saunders, managing director of the research firm GlobalData Retail, wrote in an email. "Even during recent store closeouts, Toys R Us failed to create any sense of excitement. The brand lost relevance, customers and ultimately sales."
At its heyday, Toys R Us had a towering flagship store in New York's Times Square (now closed and home to Old Navy) and a ubiquitous icon, Geoffrey the Giraffe.
"We know that customers are willing to pay more for an enjoyable experience - just look at the lines at Starbucks every day - but Toys R Us has failed to give us anything special or unique," said O'Keefe, the Virginia Commonwealth University professor. "You can find more zest for life in a Walgreens."