Flights will also be offered between Napier and Hamilton and between Napier and Nelson via Palmerston North.
Schedules will be adjusted for the Labour weekend period for people to enjoy a long weekend.
Inglis said there were currently no direct flights between Napier and Nelson.
He said the two regions shared a lot in common and there was demand for the service.
"They are both big horticulture areas and in addition to that both tourist areas.
"There are a lot of similarities between our two areas and the message we are receiving is people would like to be able to make a direct flight for a long weekend."
Originair has a fleet of three, 18-seat Jetstream planes and offers scheduled flights and charter flights.
It currently operates between Nelson, Palmerston North, Hamilton and Wellington. Hawke's Bay will be its fifth destination.