Shares of Hewlett-Packard slumped, last 11.1 per cent weaker, after the company predicted profit for fiscal 2013 that fell short of expectations.
Investors are now focused on the September jobs report due on Friday. The jobless rate in the US probably rose to 8.2 per cent last month from 8.1 per cent in August, while payrolls increased by 115,000 in September, less than the 139,000 average over the first eight months of the year, economists polled by Bloomberg predicted.
The latest economic data from Europe showed that times remain challenging. Euro-zone services and manufacturing output shrank for an eighth month.
At a four-month low of 46.1 in September, little changed from 46.3 in August, the Markit Eurozone PMI Composite Output Index was slightly above its earlier flash estimate of 45.9. A bright spot came in retail sales, which advanced 0.1 per cent in August from July, the European Union's statistics office said.
In Europe, the Stoxx 600 Index finished the session with 0.1 per cent decline on the previous close. However, national benchmark stock indexes in the UK and Germany ended the day with gains of 0.3 per cent and 0.2 per cent respectively.
Meanwhile, the slowdown in the pace of growth of the world's No. 2 economy continues. China's purchasing managers' index dropped to 53.7 in September from 56.3 in August, according to the National Bureau of Statistics and China Federation of Logistics and Purchasing in Beijing.
The latest report out of China underpins hope the government will inject fresh stimulus to rekindle the pace of expansion.
It "increased the likelihood that the Chinese central bank or some other mechanism is focusing on providing liquidity to the economy," Thomas Sowanick, chief investment officer of Omnivest Group in Princeton, New Jersey, told Bloomberg.