Diehard fans of the airline are also planning their own celebrations.
"We'll be having a get-together in the gate area before the flight," frequent flyer Nate Vallier, who owns an airline IT company, told USA Today.
"We'll have posters, memorabilia and other swag to hand out and, after the flight, we'll be gathering in the Alaska Airlines lounge in LAX to toast to the sunset of the Virgin America brand."
By morning, all check-in counters, kiosks, signs and gate areas branded as Virgin America will vanish from 29 airports around the US and Mexico. The livery and planes will go at a later date.
Usually passengers love to hate airlines, but not Virgin — the airline had a 7/10 rating on Skytrax and was famous for its safety video.
Dismayed travellers have flooded social media to pay tribute to the carrier.
Farewell, Virgin America. You will be missed.