Armed officers were called and attended the 98-storey building located on North Wabash Ave.
However, the incident was not thought to be related to the Trump family.
The Sun-Times stated that police sent officers to the building’s 27th floor where a woman went after saying she was “tired of being abused by her husband”.
The tower contains a Trump Hotel as well as apartments.
A resident of the skyscraper told local radio station WBBM that he had come down to street level to get some air when he was confronted by armed police.
“I came down to the lobby and I was quickly escorted away, out of the building and was told not to come back until it was clear,” the man, known as Steve, said.
“I asked several times what was going on and they wouldn’t acknowledge”.
No one has yet been allowed back into the building and the surrounding streets have been sealed off.
Chicago police said in a statement there was “no threat to the public” but did not give details of the incident.
