The EP also sees the band pay tribute to Renee Good, an American woman who was shot dead by a federal agent as she protested against Immigration and Customs Enforcement (ICE) operations in January.
In the opening track American Obituary, Bono sings: “Renee Good born to die free”.
The band said they would release a new album later this year.
Formed in the 1970s, U2 became one of the world’s most prominent rock bands through hits like With or Without You and Beautiful Day and their vocal human rights campaigning.
Bono, 65, is well-known for his activism to eradicate poverty and fight Aids, and has been outspoken against wars in Ukraine, Sudan and Gaza in recent years.
Song of the Future honours a teenage girl who died while protesting in Iran in 2022, while One Life at a Time criticises Israeli settler activity in the occupied West Bank.
The latest EP builds on U2’s 2017 album Songs of Experience, which included tracks urging activism and tolerance, released after Donald Trump’s first election as US President.
-Agence France-Presse