As part of the study, the men will be given flu jabs to shed light on how space changes the immune system. They will also have their full genomes mapped.
Craig Kundrot, deputy chief scientist of Nasa's human research programme, said: "This is a unique opportunity. We can study two individuals who have the same genetics but are in different environments for one year."
Mark Kelly and his wife former Congresswoman Gabrielle Giffords. Photo / AP
For the Kelly brothers, who are both 50, the experiment, which will also continue once Scott returns to Earth, is the latest in the long pattern of coincidence that defines their lives. After graduating they became US Navy captains and were selected for both the same test pilot and then astronaut training classes.
They have also both flown as pilot and commander of space shuttle missions.
Mark Kelly, who has been into space four times, is married to Gabrielle Giffords, the former Congresswoman who was shot in the head in 2011 during an apparent assassination attempt and astonished many with her recovery.
The twins, who came up with the idea of the study, are ready to go to extraordinary lengths to gather new data.
Scott told the New York Times: "I volunteered to have them put a pressure probe in my skull. I thought it would be kind of cool to have a little bolt."
- THE INDEPENDENT