The decision is the latest twist in American leaders' unsuccessful quest to craft a solution for Syria's long civil conflict, which has drawn in US allies and adversaries including Turkey, Russia and Iran.
Both the Trump and Obama administrations have resisted becoming more involved in Syria's larger civil war but many senior officials - including at the State Department and Pentagon - have supported an ongoing troop presence in Syria until security conditions improve and a political solution can be reached.
Defence officials, speaking on condition of anonymity to discuss a decision that has not yet been announced, said the withdrawal was expected to occur as quickly as possible and would affect the entire force of more than 2,000 US service members. The Wall Street Journal first reported on Wednesday that US troops would be removed from northeast Syria.
US forces are mostly in north central and northeast Syria, but they also have a smaller ground presence in the southeast Syria along the border with Jordan.
The unexpected White House move comes as tensions increase sharply with NATO ally Turkey, which has promised to launch a military offensive against the US partner forces in Syria, which Ankara considers part of a Kurdish terrorist group. Losing their US ground partner will be a major blow to the Syrian Kurdish forces.