Flood warnings have been issued for the Calliope, Boyne, Baffle and Kolan Rivers.
The Local Disaster Management Group at Gladstone said flood levels along the Boyne River were to exceed one in 100 flood levels on the morning high tide at 8.45am (AEST) on Saturday and evening high tide at 9pm.
Mayor Gail Sellers said the tide is expected to back up in Tannum Sands and Boyne Island.
"At the moment, police and emergency services are down in that area door-knocking. They are asking people to evacuate," she told ABC radio.
The State Emergency Service (SES) has received more than 650 requests for assistance since Friday morning, including more than 130 for Rockhampton, and more than 35 jobs each for Gladstone and Yeppoon.
A person was rescued in Smoky Creek, west of Gladstone, about 1am after their car was caught in floodwaters.
The Bruce Highway is closed in several places between Rockhampton and Gladstone, and phone and internet connections are down in places.
Queensland Rail says the train line is cut near Rockhampton and there are no services between Brisbane and Cairns.
-AAP