Puzzle of the Elephant Man probed

Joseph Merrick, the Elephant Man. Photo / AP

He was the thing of children's nightmares, outcast by a Victorian society unable to comprehend his grotesque deformities, but was later immortalised in theatre and cinema.

Joseph Merrick, better known as the Elephant Man, is one of medical history's enigmas: 122 years after his death, no one knows exactly what caused his extreme disfigurement. But scientists will try to solve the puzzle next month by extracting DNA from his bones for analysis.

Merrick came to the attention of the medical profession in the 1880s. Ever since, scientists have struggled to explain the huge growths that caused him to be first shunned and then celebrated by society - by the end of his life his courage and humility had, at last, been recognised.

Merrick became a folk hero for speaking up for others who were similarly afflicted.

It was initially thought that he suffered from elephantiasis, a parasitic infection characterised by the thickening and enlargement of skin and tissue, hence his nickname.

Then, in 2001, some scientists suggested that Merrick had suffered from a rare disease called Proteus syndrome - a congenital disorder that causes skin overgrowth and abnormal bone development. But other experts questioned the diagnosis, saying that the way his disease manifested itself was not typical of that condition. It is hoped the latest research will finally prove conclusive.

Scientists will extract DNA from Merrick's skeleton, which has been kept at the Royal London Hospital at Whitechapel, east London, since his death, aged 27, in 1890. Tests will then be carried out to see if it is possible to sequence Merrick's genome thereby identifying any gene alteration. Researchers hope that by diagnosing his condition, they will be able to treat other sufferers.

Professor Richard Trembath, vice-principal and executive dean at Queen Mary, University of London, who is overseeing the research, said: "This is going to be extremely demanding. We know we can get genetic material out of the bone of Merrick. We need to know whether we can get sufficient from what we believe to be abnormal bone as well as sufficient from normal bone.

"We have an absolute regard to make sure we preserve the skeleton. We can't just mash a whole amount of it up. We have to preserve it for future generations because it's an important historical record."

A LIFE IN THE PUBLIC EYE

Joseph Merrick was born in Leicester in 1862. He was rejected by his father and stepmother and forced on to the street to earn a living, wearing a cap and hood in an attempt to hide his disfigurement. He finally took a job as a sideshow "freak", exhibited as a curiosity.

It wasn't until surgeon Frederick Treves took him under his wing and brought him to the London Hospital, where he lived out his final years, that he became something of a celebrity.

Bradley Cooper is starring in a stage adaptation of The Elephant Man, and David Lynch's 1980 film of the same name earned several Oscar nominations.

- Independent