"Flash flooding and debris flows will be a particular threat in and below the recently burned areas," the National Weather Service said in a bulletin on Friday.
The inclement weather sweeping into the region was being carried on a current with the unlikely name "Pineapple Express" - an intense stream of moisture stretching from Hawaii to the US West Coast.
"It's clearly the strongest storm to impact the West Coast in the last three years," Todd Morris, a spokesman for the National Weather Service, told AFP.
Blizzard warnings were issued for mountainous areas, the first such alerts since 2008, with up to a metre of snow expected.
Hundreds of flights were cancelled on Thursday at San Francisco International Airport, but Los Angeles International Airport on Friday reported no increase in major delays.
Flashflood watches and warnings were in place all along the western United States from the Pacific northwest to San Diego at the Golden State's southernmost tip.
- AAP