Police have now urged anyone who saw Karlie or Khandalyce travelling around Australia in the last 10 years to call Crimestoppers.
Karlie was born in Alice Springs in 1988 and gave birth to Khandalyce there in 2006.
Sometime between 2006 and 2008 she moved out of home and away from her loving family, deciding to travel around Australia and work.
Karlie was 20 when she was last seen driving near Coober Pedy with her two-year-old daughter Khandalyce in November, 2008.
Her car was pulled over by a police officer near Coober Pedy, NSW Police Homicide Squad Commander Mick Willing told reporters.
An unconfirmed sighting placed her at a shopping centre in the ACT a month later.
"Investigators...are determined to find and locate the person or persons responsible for these horrific crimes," he said.
"I can't comment about the cause of death for either the mother or the child other than to say they were violent, horrific deaths.
Family, including Khandalyce's father and Karlie's stepfather and stepbrother, have been ruled out as suspects.