The anti-gangs squad involves officers from the federal police, tax office, customs, immigration, the welfare agency Centrelink and the Crime Commission and other investigators co-ordinated by a new Gangs Intelligence Co-ordination Centre launched last year.
"The police I've spoken to are convinced, absolutely convinced, that many, many, many years ago these bikie gangs lost any innocent social purpose they might have had," Prime Minister Tony Abbott said in Perth.
"They've basically become criminal conspiracies, criminal networks - prostitution, drugs, money-laundering - a whole gamut of crime over and above just random, spontaneous crime."
The commission says bikie gang members are major producers of amphetamines and heavily involved in other illicit drug markets, vehicle rebirthing and firearms trafficking.
They have also moved into crimes including serious fraud, money laundering, extortion, prostitution, property crime and bribing and corrupting officials.
The commission says the gangs collaborate with ethnic crime groups in drug and other criminal operations, and insulate themselves from prosecution through alliances that hand high-risk work to street gangs.
They are also increasingly tapping into international connections with overseas chapters and what the commission says are sophisticated and high-threat organised crime groups operating in Australia and abroad.