Local, state and federal authorities communicated with suspects in online chatrooms, who then went looking to hire children who they thought were being peddled for prostitution.
Among the 104 suspects were a former youth director at a church, Christian Gibson, 26, and an emergency room doctor, Austin Kosier, 31, who has since been suspended.
Dozens of suspects were charged with "solicitation" over the three-day operation, which ended on September 13.
Instead of finding the children, the men ran into armed authorities who took them into custody. In some cases, female investigators posed as live decoys.
"I'm helping put bad guys away," one of the undercover officers told NBC 4 in Columbus. "I'm 27, and I pose as a 14-year-old or 15-year-old."
Another female officer posed as a young boy, to reassure the suspects they were not being set up.
"This operation demonstrates the varying dynamics of sex trafficking in our community," said Ohio Human Trafficking Task Force Director Sergeant Mark Rapp.