The new resolution is tantamount to a complete economic blockade of North Korea, the ministry said.
"We define this 'sanctions resolution' rigged up by the US and its followers as a grave infringement upon the sovereignty of our Republic, as an act of war violating peace and stability in the Korean peninsula and the region and categorically reject the 'resolution'."
North Korea on November 29 said it successfully tested a new ICBM that put the US mainland within range of its nuclear weapons.
North Korea's nuclear weapons are a self-defensive deterrence not in contradiction of international law, its foreign ministry added.
"We will further consolidate our self-defensive nuclear deterrence aimed at fundamentally eradicating the US nuclear threats, blackmail and hostile moves by establishing the practical balance of force with the U.S," the ministry said.
"The US should not forget even a second the entity of the DPRK which rapidly emerged as a strategic state capable of posing a substantial nuclear threat to the US mainland," it added, using the country's official name, the Democratic People's Republic of Korea.
North Korea said those who voted for the sanctions would face Pyongyang's wrath. "Those countries that raised their hands in favour of this 'sanctions resolution' shall be held completely responsible for all the consequences to be caused by the 'resolution' and we will make sure for ever and ever that they pay heavy price for what they have done."
Tension has been rising over North Korea's nuclear and missile programs, which it pursues in defiance of years of UN Security Council resolutions, with bellicose rhetoric coming from both Pyongyang and the White House.
- AAP