A major Melbourne intersection had to be sectioned off after a snake was found near Southern Cross Station.

The reptile was found near the corner of Collins and Spencer streets, close to Southern Cross Station, news.com.au reports.

Police have formed a cordon around the creature as they await a snake catcher, with the unusual sight drawing a large crowd which has spilt onto Spencer St.

One southbound lane of Spencer St had to be closed.

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City of Melbourne posted a photo of the snake on Twitter and urged people to avoid the area.

"We're currently trying to remove a snake who seems to be a little lost," the council wrote.

Metro Trains also urged passengers travelling to or from Southern Cross station to take extra precaution.