The former first lady is expected to be the clear Democratic front-runner in the race to succeed Obama.
The wife of former president Bill Clinton leads opinion polls among Democrats, some 60 per cent of whom say they would vote for her in the primaries, according to the website RealClearPolitics.
Two other potential candidates - Senator Elizabeth Warren and Vice President Joe Biden - have not yet said they intend to run.
On the Republican side, Senators Rand Paul and Ted Cruz have already thrown their hats into the ring, with more candidates likely to follow - including Jeb Bush, former governor of Florida, brother to president George W Bush and son of president George HW Bush.
A series of polls this year have consistently placed Clinton ahead of every one of her potential Republican challengers, although the gap has narrowed in recent weeks.
- AAP